Blar i forfatter "Mortensen, Kim Erlend"

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    • Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial 

      Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik; Hemmingsson, Oskar; Isaksson, Bengt; Juel, Ingebjørg Soterud; Larsen, Peter Nørgaard; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Rizell, Magnus; Sandström, Per; Sandvik, Oddvar Mathias; Sparrelid, Ernesto; Taflin, Helena; Taskén, Kjetil; Brudvik, Kristoffer Watten; Fretland, Åsmund Avdem; Horn, Arild; Kleive, Dyre; Labori, Knut Jørgen; Lassen, Kristoffer; Røsok, Bård Ingvald; Søreide, Jon Arne; Tholfsen, Tore; Villanger, Olaug; Waage, Anne (Journal article; Tidsskriftartikkel, 2021-09-20)
      Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ...

    • Autofluorescence in freshly isolated adult human liver sinusoidal cells 

      Larsen, Anett Kristin; Simon-Santamaria, Jaione; Elvevold, Kjetil; Ericzon, Bo Gøran; Mortensen, Kim Erlend; McCourt, Peter Anthony; Smedsrød, Bård; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      Autofluorescent granules of various sizes were observed in primary human liver endothelial cells (LSECs) upon laser irradiation using a wide range of wavelengths. Autofluorescence was detected in LAMP-1 positive vesicles, suggesting lysosomal location. Confocal imaging of freshly prepared cultures and imaging flow cytometry of non-cultured cells revealed fluorescence in all channels used. Treatment ...

    • Centralizing a national pancreatoduodenectomy service: striking the right balance 

      Nymo, Linn Såve; Kleive, Dyre; Waardal, Kim; Bringeland, Erling Audun; Søreide, Jon Arne; Labori, Knut Jørgen; Mortensen, Kim Erlend; Søreide, Kjetil; Lassen, Kristoffer (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-07)
      <i>Background</i> - Centralization of pancreatic surgery is currently called for owing to superior outcomes in higher‐volume centres. Conversely, organizational and patient concerns speak for a moderation in centralization. Consensus on the optimal balance has not yet been reached. This observational study presents a volume–outcome analysis of a complete national cohort in a health system with ...

    • The effects of terlipressin and direct portacaval shunting on liver hemodynamics following 80% hepatectomy in the pig 

      Hammond, John S.; Godtliebsen, Fred; Steigen, Sonja Eriksson; Guha, I. Neil; Wyatt, Judy; Revhaug, Arthur; Lobo, Dileep N.; Mortensen, Kim Erlend (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-15)
      Liver failure is the major cause of death following liver resection. Post-resection portal venous pressure (PVP) predicts liver failure, is implicated in its pathogenesis, and when PVP is reduced, rates of liver dysfunction decrease. The aim of the present study was to characterize the hemodynamic, biochemical, and histological changes induced by 80% hepatectomy in non-cirrhotic pigs and determine ...

    • The genetic regulation of the terminating phase of liver regeneration 

      Nygård, Ingvild Engdal; Mortensen, Kim Erlend; Hedegaard, Jakob; Conley, Lene N; Kalstad, Trine; Bendixen, Christian; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      After partial hepatectomy (PHx), the liver regeneration process terminates when the normal liver-mass/body-weight ratio of 2.5% has been re-established. To investigate the genetic regulation of the terminating phase of liver regeneration, we performed a 60% PHx in a porcine model. Liver biopsies were taken at the time of resection, after three weeks and upon termination the sixth week. Gene expression ...

    • The impact of partial hepatectomy on oxidative state in the liver remnant - An in vivo swine model 

      Florholmen-Kjær, Åse; Goll, Rasmus; Fuskevåg, Ole-Martin; Nygård, Ingvild; Paulssen, Ruth H; Revhaug, Arthur; Mortensen, Kim Erlend (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-05-24)
      Background Previous studies on oxidative state after partial hepatectomy (PHx) report conflicting data on levels of glutathione (GSH) and are mainly presented in rodent models by methodology less sensitive than the present technologies. The current swine model presents GSH levels and the following genetic response post-PHx, utilizing an analytical platform more sensitive and precise than earlier ...

    • Increased sinusoidal flow is not the primary stimulus to liver regeneration 

      Conley, Lene N.; Mortensen, Kim Erlend; Nygaard, Ingvild; Sorenesen, Peter; Mortensen, Elin; Bendixen, Christian; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-01-20)
      Background: Hemodynamic changes in the liver remnant following partial hepatectomy (PHx) have been suggested to be a primary stimulus in triggering liver regeneration. We hypothesized that it is the increased sinusoidal flow per se and hence the shear-stress stimulus on the endothelial surface within the liver remnant which is the main stimulus to regeneration. In order to test this hypothesis we ...

    • Increased sinusoidal flow is not the primary stimulus to liver regeneration 

      Conley, LN; Mortensen, Kim Erlend; Nygård, Ingvild; Sørensen, Peter; Mortensen, Elin; Bendixen, C; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)

    • Liver regeneration : the impact of altered portal hemodynamics on gene expression and growth of the porcine liver 

      Mortensen, Kim Erlend (Doctoral thesis; Doktorgradsavhandling, 2010-12-10)
      Previous research on liver regeneration has focused on the volume and composition of the blood perfusing the liver remnant and their relative importance in initiating the cascade of liver regeneration after partial hepatectomy. Newer studies around year 2000 indicated nitric oxide was of paramount importance due to the increased shear stress in liver sinusoids. On the basis of experimental liver ...

    • Liver Regeneration in Surgical Animal Models - A Historical Perspective and Clinical Implications 

      Mortensen, Kim Erlend; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2010-12-07)
      Methods/Aims: Despite improved preoperative evaluation, surgical techniques and perioperative intensive care, some patients still experience postoperative liver failure in part due to insufficient regeneration. The aim of this review is to give the reader a historical synopsis of the major trends in animal research on liver regeneration from the early experiments in 1877 up to modern investigation. ...

    • Performance and clinical applicability of machine learning in liver computed tomography imaging: a systematic review 

      Radiya, Keyur; Joakimsen, Henrik Lykke; Mikalsen, Karl Øyvind; Aahlin, Eirik Kjus; Lindsetmo, Rolf Ole; Mortensen, Kim Erlend (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-12)
      Objectives Machine learning (ML) for medical imaging is emerging for several organs and image modalities. Our objectives were to provide clinicians with an overview of this field by answering the following questions: (1) How is ML applied in liver computed tomography (CT) imaging? (2) How well do ML systems perform in liver CT imaging? (3) What are the clinical applications of ML in liver CT ...

    • Practice patterns in diagnostics, staging, and management strategies of gallbladder cancer among Nordic tertiary centers 

      Takala, Sini; Lassen, Kristoffer; Søreide, Kjetil; Sparrelid, Ernesto; Angelsen, Jon-Helge; Bringeland, Erling Audun; Eilard, Malin S.; Hemmingsson, Oskar; Isaksson, Bengt; Karjula, Heikki; Lammi, Jukka-Pekka; Larsen, Peter N.; Lavonius, Maija; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Nordin, Arno; Pless, Torsten; Sandström, Per; Sandvik, Oddvar Mathias; Vaalavuo, Yrjö; Villard, Christina; Sallinen, Ville (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-28)
      Background and objective: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries and no common Nordic treatment guidelines exist. This study aimed to characterize the current diagnostic and treatment strategies in the Nordic countries and disclose differences in these strategies. Methods: This was a survey study with a cross-sectional questionnaire of all 19 university hospitals ...

    • Tissue remodelling following resection of porcine liver 

      Nygård, Ingvild; Mortensen, Kim Erlend; Hedegaard, Jakob; Conley, Lene Nagstrup; Bendixen, Christian; Sveinbjørnsson, Baldur; Revhaug, Arthur (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06)
      Aim. To study genes regulating the extracellular matrix (ECM) and investigate the tissue remodelling following liver resection in porcine. <p>Methods. Four pigs with 60% partial hepatectomy- (PHx-) induced liver regeneration were studied over six weeks. Four pigs underwent sham surgery and another four pigs were used as controls of the normal liver growth. Liver biopsies were taken upon laparotomy, ...